Publications (Dr. Li’s Lab)

Pattali R, Mou Y, Li XJ*. AAV9 Vector: a Novel modality in gene therapy for spinal muscular atrophy. Gene Ther. 2019 Jun 26. PMID: 31243392 

Wang Y, Xu C, Ma L, Mou Y, Zhang B, Zhou S, Tian Y, Trinh J, Zhang X, Li XJ*. Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology. Life Sci Alliance. 2019 Apr;2(2). Print 2019 Apr. PubMed PMID: 30910806; PMID: 30910806. PMCID: PMC6435041

Mou Y, Li XJ*. Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias. Neural Regen Res. 2019 Apr;14(4):574-577. PubMed PMID: 30632492; PubMed Central PMCID: PMC6352593

Bijukumar DR, Segu A, Mou Y, Ghodsi S, Shokufhar T, Barba M, Li XJ, Mathew MT. Differential toxicity of processed and non-processed states of CoCrMo degradation products generated from a hip simulator on neural cells, Nanotoxicology. 2018 Nov;12(9):941-956. PubMed PMID: 30251573; PubMed Central PMCID: PMC6379144.

Denton K, Mou Y, Xu CC, Shah D, Chang J, Blackstone C, Li XJ*. Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias. Hum Mol Genet. 2018 Jul 15;27(14):2517-2530. PubMed PMID: 29726929; PubMed Central PMCID: PMC6031053.

Knowlton S, Cho YK, Li XJ, Khademhosseini A, Tasoglu S. Utilizing Stem Cells for Three-Dimensional Neural Tissue Engineering (Review Article). Biomaterials Science. 2016 May 26;4(5):768-84. doi: 10.1039/c5bm00324e. Epub 2016 Feb 18. PMID: 26890524.

Xu CC, Denton KR, Wang ZB, Zhang X, Li XJ*. Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy. Disease Models & Mechanisms. 2016 Jan 1;9(1):39-49. PubMed PMID: 26586529; PubMed Central PMCID: PMC4728333.

Denton K, Xu CC, Li XJ*. Modeling axonal phenotypes with human pluripotent stem cells. Methods Mol. Biol. 2016;1353:309-21. doi: 10.1007/7651_2014_167. PMID: 25520289.

Boisvert EM, Engle SJ, Hallowell SE, Liu P, Wang ZW, Li XJ*. The specification and maturation of nociceptive neurons from human embryonic stem cells. Scientific Reports. 2015, 5: 16821. PubMed PMID: 26581770; PubMed Central PMCID: PMC4652175.

Liu HS, Lu JF, Chen H, Du ZW, Li XJ, Zhang SC. Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability. Scientific Report. 2015 Jul 20; 5:12189. doi: 10.1038/srep12189. PMID: 26190808. PMCID: PMC4507262.

Chen T, Xiang JF, Zhu S, Chen S, Yin QF, Zhang XO, Zhang J, Feng H, Li XJ, Yang Li, Chen LL. ADAR1 is required for differentiation and neural induction by regulating microRNA processing in a catalytically independent manner. Cell Research. 2015, 25(4):459-76. doi: 10.1038/cr.2015.24. PMID: 25708366. PMCID: PMC4387555.

Zhu PP, Denton K, Renvoise B, Pierson TM, Li XJ*, Blackstone C. Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A. Hum Mol Genet. 2014, 23(21):5638-48. doi: 10.1093/hmg/ddu280. PMID: 24908668. PMCID: PMC4189900.

Denton K, Lei L, Grenier J, Rodionov V, Blackstone C, Li XJ*. Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia. Stem Cells. 2014, 232(2):414-23. doi: 10.1002/stem.1569. PMID: 24123785. PMCID: PMC3947148.

Boisvert E, Denton K, Lei L, Li XJ*. Specification of telencephalic glutamatergic neurons from human pluripotent stem cells. Journal of Visualized Experiments. 2013, 74. doi: 10.3791/50321. PMID: 23603787. PMCID: PMC3656538.

Martins-Taylor K, Wang X, Li XJ, and Xu RH. Stem Cells and Tissue Regeneration. In:  Laurencin CT, Khan Y. eds. Regenerative Engineering, 2013 (Book Chapter).

Wang ZB, Zhang X, and Li XJ*. Recapitulation of spinal motor neuron-specific disease phenotypes in a human cell model of spinal muscular atrophy. Cell Research. 2013, 23(3):378-93. doi: 10.1038/cr.2012.166. PubMed PMID: 23208423; PubMed Central PMCID: PMC3587706.

Zhan H, Moore CS, Chen B, Zhou X, Ma XM, Ijichi K, Bennett M, Li XJ, Crocker S, Wang ZW. Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal.  PLoS ONE. 2012, 7(6):e39489. doi: 10.1371. PMID: 22768083. PMCID: PMC3387187.

Wang ZB, Boisvert E, Zhang X, Guo M, Fashoyin A, Du ZW, Zhang SC, Li XJ*. Fezf2 regulates telencephalic precursor differentiation from mouse embryonic stem cells. Cerebral cortex. 2011, 21:2177-2186. PubMed PMID: 21330470; PubMed Central PMCID: PMC3155607.  

Zeng H, Guo M, Martins-Taylor K, Wang XF, Zhang Z, Park JW, Zhan SN, Kronenberg MS, Lichtler A, Liu HX, Chen FP, Yue L, Li XJ*, Xu RH*. Specification of Region-specific Neurons Including Forebrain Glutamatergic Neurons from Human Induced Pluripotent Stem Cells. PLoS One. 2010, 5 (7):e11853. PubMed PMID: 20686615; PubMed Central PMCID: PMC2912324.

Zhang X, Huang CT, Chen J, Pankratz MT, Xi J, Li J, Yang Y, LaVaute TM, Li XJ, Ayala M, Bondarenko GI, Du ZW, Jin Y, Golos TG, Zhang SC. Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell. 2010, 7: 90-100. PubMed PMID: 20621053; PubMed Central PMCID: PMC2904346.

Li XJ*, Zhang X, Johnson MA, Wang ZB, LaVaute TM, Zhang SC. Coordination of Sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development. 2009, 136: 4055-4063. PubMed PMID: 19906872; PubMed Central PMCID: PMC2778748

Zeng H, Park JW, Guo M, Lin G, Crandall L, Compton T, Wang X, Li XJ, Chen FP, Xu RH. Lack of ABCG2 Expression and Side Population Properties in Human Pluripotent Stem Cells. Stem Cells. 2009, 27:2435-2445. PubMed PMID: 19670287.

Hu BY, Du ZW, Li XJ, Ayala M, Zhang SC. Human Oligodendrocytes from Embryonic Stem Cells: Conserved SHH Signaling Networks and Divergent FGF Effects. Development. 2009, 136:1443-1452. PubMed PMID: 19363151; PubMed Central PMCID: PMC2674255.

Li XJ, Hu BY, Jones SA, Zhang YS, LaVaute TM, Du ZW, Zhang SC. Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells. 2008, 26:886-893. PubMed PMID: 18238853; PubMed Central PMCID: PMC2707816.

Chamberlain SJ, Li XJ, Lalande M. Induced pluripotent stem (iPS) cells as in vitro models of human neurogenetic disorders (review). Neurogenetics. 2008, 9:227-235. PMID: 18791750.

Li XJ, Yang DL, Zhang SC. Motoneuron and dopamine neuron differentiation. In: Loring J, Wesselschmidt R, Schwartz P. eds. Human Stem Cell Manual: a Laboratory Guide. Spiral Bound, 2008 (Book Chapter).

Zhang SC, Li XJ, Johnson MA, Pankratz M. Human embryonic stem cells for brain repair (review). Philosophical Transactions: Biological Sciences. 2008, 363:87-99. PMID: 17322002. PMCID: PMC2605488.

Pankratz MT, Li XJ, LaVaute TM, Lyons EA, Chen X, Zhang SC. Directed Neural Differentiation of hESCs via an Obligated Primitive Anterior Stage. Stem Cells. 2007, 25:1511-1520. PMID: 17332508. PMCID: PMC2743478.

Du ZW, Li XJ, Nguyen GD, Zhang SC. Induced expression of Olig2 is sufficient for oligodendrocyte specification but not for motoneuron specification and astrocyte repression. Mol. Cell. Neurosci. 2006, 33:371-380. PMID: 17035043.

Li XJ, Zhang SC. In vitro differentiation of neural precursors from human embryonic stem cells. In: Turksen K eds. Human Embryonic Stem Cell Protocols. Human Press Inc., 2006. PMID: 16881517.

Guillaume D, Johnson A, Li XJ, Zhang SC. Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. J. Neurosci. Res. 2006, 84:1165-1176. PMID: 16941479. PMCID: PMC2735209.

Li XJ, Du ZW, Zarnowska ED, Pankratz M, Hansen LO, Pearce RA, Zhang SC. Specification of motoneurons from human embryonic stem cells. Nature Biotechnology. 2005, 23: 215-221. PMID: 15685164.

Chen LJ, Gao YQ, Li XJ, Shen DH, Sun FY. Melatonin protects against MPTP/MPP+ -induced mitochondrial DNA oxidative damage in vivo and in vitro. J. Pineal Res. 2005, 39:34-42. PMID: 15978055.

Li XJ, Gu J, Lu SD, Sun FY. Melatonin attenuates MPTP-Induced dopaminergic neuronal injury associated with scavenging hydroxyl radical. J. Pineal Res. 2002, 32: 47-52. PMID: 11841600.

Li XJ, Sun FY. Molecular mechanisms in neurodegenerative disease (review). Chinese Journal of Neuroscience 2001, 17: 379-384.

Ling X, Zhang LM, Lu SD, Li XJ, Sun FY. Protection of melatonin against injured cerebral neurons is associated with bcl-2 protein over-expression. Acta Pharmacol. Sin. 1999, 20: 409-414. PMID: 10678086.

Li XJ, Gu J, Pan BS, Sun FY. Effect of melatonin on the production of hydroxyl radical and LDH during anoxia in rat cortical slice. Acta Pharmacol. Sin. 1999, 20: 201-205. PMID: 10452092.

Gu J, Li XJ, Sun FY. Melatonin decreases the release of amino acid transmitters in hypoxic rat cortical slice. Sheng Li Xue Bao. 1999, 51: 445-448. PMID: 11498975.

Li XJ, Sun FY. Hydroxyl radical and cerebral ischemia (review). Chinese Pharmacol. Bulletin 1998, 14: 44-48.

Li XJ, Zhang LM, Gu J, Zhang AZ, Sun FY. Melatonin decreases product of hydroxyl radical during cerebral ischemia-reperfusion. Acta Pharmacol. Sin. 1997, 18: 394-396. PMID: 10322924.

Li XJ, Pan BS, Zhang LM, Gu J, Gu YJ, Sun FY. Measurement of hydroxyl radicals in rat brain in vivo. Acta Acad. Med. Shanghai 1997, 24: 299-301.


For Complete list of publication in PubMed: